Azithromycin: What It Treats and How to Use It Safely

Azithromycin is a popular antibiotic you’ve probably heard called a Z‑Pak. Doctors prescribe it for ear infections, certain sinus and throat infections, some chest infections, and sexually transmitted infections like chlamydia. It’s praised for short courses and convenient dosing, but it’s still a real drug with real risks. Here’s the plain talk you need to use it wisely.

How azithromycin is usually taken

The most common regimen is the Z‑Pak: 500 mg on day one, then 250 mg once daily on days two through five. For some infections, a single higher dose or a different schedule may be used — your prescriber will choose based on the bug and severity. You can take azithromycin with or without food, though a light meal often helps if the pills upset your stomach.

Missed a dose? Take it as soon as you remember. If it’s almost time for the next dose, skip the missed one — don’t double up. Finish the full course, even if you feel better before it’s done. Stopping early raises the chance the bacteria become resistant.

Side effects, interactions, and safety tips

Most people tolerate azithromycin, but expect possible stomach upset, diarrhea, nausea, or headache. If you develop severe diarrhea, an allergic reaction, jaundice, or a racing heartbeat, contact a healthcare provider immediately. Azithromycin can affect heart rhythm in some people, especially those already taking drugs that prolong the QT interval — mention all current meds to your prescriber.

Azithromycin is processed by the liver, so tell your doctor if you have liver disease. It’s usually safe in pregnancy when needed, but discuss risks and benefits with your clinician. Avoid alcohol if you develop significant liver symptoms while on treatment.

Resistance is a growing problem. Don’t use azithromycin for viral illnesses like colds or most sore throats unless a doctor confirms a bacterial cause. If you’ve recently taken macrolide antibiotics or live in an area with high resistance, your doctor may pick a different antibiotic.

Practical tips: keep a list of your medications and health issues to show your provider; report side effects quickly; don’t share antibiotics; and store medicines in a cool, dry place. If buying medicines online, use licensed pharmacies and check reviews and contact information first.

Want more on antibiotics and safer choices? Browse guides about alternatives, dosing details, and how to spot shady online pharmacies right here on Canada Pharmacy 365.